Identifying differentially expressed genes using the Polya urn scheme
نویسندگان
چکیده
منابع مشابه
Multivariate methods for identifying differentially expressed genes
Motivation: Univariate testing procedures remain the most common way to identify differentially expressed genes (DEGs). Univariate techniques suffer from the multiple comparison problem and reduced power, because they fail to account for gene interaction. Motivated by these issues, we adopt a multivariate procedure. Namely, we utilize the sup-norm test, which was specifically developed for high...
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MOTIVATION DNA microarrays have recently been used for the purpose of monitoring expression levels of thousands of genes simultaneously and identifying those genes that are differentially expressed. The probability that a false identification (type I error) is committed can increase sharply when the number of tested genes gets large. Correlation between the test statistics attributed to gene co...
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A very simple specific case of a Polya urn scheme is as follows. At each trial one draws a ball from an urn with balls of two different colours. Then, one looks at the ball, and returns the ball to the urn together with another ball of the same colour. Then one makes another draw. Et cetera. At the first draw there is one ball of each colour. The rechargeable Polya urn scheme is essentially the...
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For the classical Polya urn model parametrized by exponent γ, the limit distributions of the fraction of balls in each bin are simple and well known when γ < 1 (“egalitarian”) and when γ > 1 (“winner takes all”). In this note, we partially fill in the gap for γ = 1, the critical point, by providing explicit analytical expressions for all the moments of the limit distribution of the fraction of ...
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ژورنال
عنوان ژورنال: Communications for Statistical Applications and Methods
سال: 2017
ISSN: 2383-4757
DOI: 10.29220/csam.2017.24.6.627